簡(jiǎn)體
城鄉(xiāng)建設(shè)與生活
服務(wù)商
city & town developer &
service provider
杜杰
北京市心肺血管疾病研究所 副所長(zhǎng)、國(guó)家“重點(diǎn)研發(fā)計(jì)劃精準(zhǔn)醫(yī)學(xué)專項(xiàng)”首席科學(xué)家 、2008年獲聘長(zhǎng)江學(xué)者特聘教授崗位、2008年獲國(guó)家基金委杰出青年基金資助
北京市心肺血管疾病研究所 副所長(zhǎng)
一、研究方向
心血管疾病分子病因?qū)W研究，心血管病理性重塑發(fā)病機(jī)制研究。
二、2020 年主持及參與課題
主持國(guó)家自然基金重點(diǎn)項(xiàng)目《免疫炎癥微環(huán)境促進(jìn)血管平滑肌表型轉(zhuǎn)化導(dǎo)致主動(dòng)脈夾層的機(jī)制研究》(2021/01-2024/12)，國(guó)家自然基金重大項(xiàng)目《核酸小分子和花生四烯酸代謝活性小分子調(diào)節(jié)網(wǎng)絡(luò)在病理性心肌重構(gòu)中的作用》(2018/01-2022/12)，教育部創(chuàng)新團(tuán)隊(duì)項(xiàng)目《大血管疾病轉(zhuǎn)化醫(yī)學(xué)研究》(2018/01-2020/12)，國(guó)家自然科學(xué)基金中加項(xiàng)目《歐洲和亞洲人群主動(dòng)脈瓣鈣化狹窄的遺傳基礎(chǔ)》(2019/01-2021/12)。
三、2020 年發(fā)表通訊作者
1. Li Y# , Gao S# , Han Y# , Song L, Kong Y, Jiao Y, Huang S, Du J*, Li YL*. Variants of Focal Adhesion Scaffold Genes Cause Thoracic Aortic Aneurysm. Circ Res. 2020 Oct 23. (IF= 14.467)
2. Zhang CC, Cheng NN, Qiao BK, Zhang F, Wu J, Liu C, Li YL, Du J*. Age-related decline of interferon-gamma responses in macrophage impairs satellite cell proliferation and regeneration.J Cachexia Sarcopenia Muscle. 2020 Oct;11(5):1291-1305.(IF=9.802)
3. Yang XY, Du XY, Ma K, Li GQ, Liu ZH, Rong W, Miao HT, Zhu FL, Cui QH, Wu SW, Li YL*, Du J*.Circulating miRNAs Related to Long-term Adverse Cardiovascular Events in STEMI Patients: A Nested CaseControl Study. Can J Cardiol. 2020 Mar 20;S0828-282X(20)30273-7. (IF=5)
4. Yixin Zhang, Yuan Wang, Bingbing Ke, Jie Du*. TMAO: how gut microbiota contributes to heart failure. Translational research. S1931-5244(20)30203-6 doi: 10.1016/j.trsl.2020.08.007.
5. Cheng N, Liu C, Li Y, Gao S, Han YC, Wang X, Du J*, Zhang C*. MicroRNA-223-3p promotes skeletal muscle regeneration by regulating inflammation in mice. J Biol Chem. 2020 Jul 24;295(30):10212-10223.
6. Zhang C, Cheng N, Qiao B, Zhang F, Wu J, Liu C, Li Y, Du J*. Age-related decline of IFN gamma responses in macrophage impairs satellite cell proliferation and regeneration. J Cachexia Sarcopenia Muscle, 2020.
7. Qiao B, † Nie JJ, † Shao Y, Li Y, Zhang C, Hao W, Li S, Chen D, Yu B, Li HH, Xu FJ, Du J.Functional Nanocomplexes with Vascular Endothelial Growth Factor A/C Isoforms Improve Collateral Circulation and Cardiac Function. Small. 2020 Jan;16(4):e1905925.
8. Exaggerated Autophagy in Stanford Type A Aortic Dissection: A Transcriptome Pilot Analysis of Human Ascending Aortic Tissues. Zeyi Zhou, Yan Liu , Xiyu Zhu , Xinlong Tang , Yali Wang, Junxia Wang, Can Xu , Dongjin Wang , Jie Du* , Qing Zhou*. Genes (Basel). 2020;11(10):1187. (IF=3.759)
9. Effects of Extracellular Matrix Softening on Vascular Smooth Muscle Cell Dysfunction. Shao Y, Li G, Huang S, Li Z, Qiao B, Chen D, Li Y, Liu H*, Du J*, Li P*. Cardiovasc Toxicol. 2020; 20 (6):548-556. (IF=2.284)
10.Lipocalin-2 Predicts Long-Term Outcome of Normotensive Patients with Acute Pulmonary Embolism. Yu H, Liu Z, Lu J, Yang X, Yan XX, Mi Y, Hua L, Li Y, Jing ZC, Du J. Cardiovasc Toxicol. 2020; 20(2):101-110. (IF=2.284)
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